Cardiac Ion Channels
نویسندگان
چکیده
منابع مشابه
The Cardiac Ion Channels
Action potentials are mediated by transient changes in ion conductance across the cell surface membrane. These changes in conductance are primarily mediated by ion channels. Ion channels are membrane-embedded proteins that selectively pass specific ions upon opening. Some ion channels are constitutively open; however, most channels open following stimulation, such as through voltage changes, in...
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Circus movements within the AV node as a basis for supraventricular tachycardia as shown by multiple microelectrode recording in the isolated rabbit heart – M. J. Janse and others A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell – S. Sicouri, C. Antzelevitch Membrane current through adenosine-triphosphate–regulate...
متن کاملCardiac Mechano-Gated Ion Channels and Arrhythmias.
Mechanical forces will have been omnipresent since the origin of life, and living organisms have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The cardiovascular system in general, and the heart in particular, is exposed to constantly changing mechanical signals, including stretch, compression, bending, and shear. The heart adjusts its performance to the mechanical ...
متن کاملCardiac ion channels in health and disease.
Cardiac electrical activity depends on the coordinated propagation of excitatory stimuli through the heart and, as a consequence, the generation of action potentials in individual cardiomyocytes. Action potential formation results from the opening and closing (gating) of ion channels that are expressed within the sarcolemma of cardiomyocytes. Ion channels possess distinct genetic, molecular, ph...
متن کاملRegional expression of cardiac ion channels and cardiac electrical activity
Important differences in electrophysiological properties have been noted between different regions of the heart. Electrophysiological heterogeneity has also been detected within different parts of a given tissue, such as the ventricular subendocardium, midmyocardium and subepicardium. Although many molecular candidates for native ionic currents have been identified, the molecular basis of most ...
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ژورنال
عنوان ژورنال: Circulation: Arrhythmia and Electrophysiology
سال: 2009
ISSN: 1941-3149,1941-3084
DOI: 10.1161/circep.108.789081